2019-11-13 · Salinomycin counteracts the proliferation of uveal melanoma cells. a Chemical structure of salinomycin. b Uveal melanoma (UM) cells and ARPE-19 cells were treated with a gradient concentrations of salinomycin for 72 h, and the cell viability was measured by MTS assay.
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Molecular Weight: 751.00. CAS Number: 53003-10-4. S4526. from Streptomyces albus, ≥98% (HPLC) Sigma-Aldrich. Salinomycin also suppressed the transcriptional activity mediated by β-catenin/LEF1 or β-catenin/TCF4E complex and exhibited an inhibitory effect on the sphere formation, proliferation, and anchorage-independent growth of colorectal cancer cells. Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells.
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Introduction Phenotypic heterogeneity within tumors has emerged as a key Total Structure Weight: 97.58 kDa ; Atom Count: 6732 ; Modelled Residue Count: 856 ; Deposited Residue Count: 934 ; Unique protein chains: 1 (A) Chemical structure of salinomycin. (B) MTT dose‑response curves in JIMT‑1 cells for salinomycin without modification. (C)MTT dose‑response curves in MCF‑7 cells for salinomycin without modification. (D)Purity characterization by high performance‑liquid chromatography and mass spectroscopy for salinomycin without modification. IC 2016-03-14 Salinomycin diastereoisomers and their benzoylated derivatives were synthesized and evaluated for both antiproliferative activity and neurotoxicity in vitro. The results indicated that the stereoscopic configurations of the spiro C17 and C21 atoms as well as the … Abstract The ionophore salinomycin has attracted attention for its exceptional ability to selectively reduce the proportion of cells with stem‐like properties in cancer cell populations of varying Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids By Björn Borgström, Xiaoli Huang, Eduard Chygorin, Stina Oredsson and Daniel Strand Cite The ionophore salinomycin exerts selective activity against cancer stem cells.
2. The structure of salinomycin, a new member of the polyether ant ibiotics.
2016-03-01
Salinomycin-structure.png (406 × 176 pixels, file size: 4 KB, MIME type: image/png). File information. Structured the structure-activity correlation between complexation affinity for cations, ion the antimicrobial and ion-transport activities of salinomycin and its derivatives. Salinomycin Na (CAS 55721-31-8) is a polyether ionophore with antibiotic and Focus Biomolecules supplier, chemical structure of Salinomycin Na | Cancer 23 Feb 2016 Chemical structures of salinomycin (SA) and synthetic salinomycin analogs.
Salinomycin. Molecular Formula C 42 H 70 O 11; Average mass 750.999 Da; Monoisotopic mass 750.491821 Da; ChemSpider ID 2342058
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For a structural comparison, salinomycin·Na, SY-1·Na, and 18,19-dihydro SY-1·Na were modeled using the X-ray structure of SY-1·Na as the initial geometry. (1976). Chemical Modification and Structure-Activity Correlation of Salinomycin. Agricultural and Biological Chemistry: Vol. 40, No. 8, pp.
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The twelve carbonyl groups are essential for the binding of metal ions, and also for solvation in polar solvent. The isopropyl and methyl groups are responsible for solvation in nonpolar solvents. Identification. Name.
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Domain boundaries of salinomycin synthase module 7 Figure S5. SWISS-MODEL1 ( protein structure homology-models of KR0 domains from polyether
Abstract For the first time, the crystalline complex of salinomycin with benzylamine was obtained and its molecular structure was studied using single crystal X-ray diffraction, FT-IR, 1 H NMR, 13 C NMR, 2D NMR and ESI MS methods. The polyether ionophore salinomycin has recently gained attention due to its exceptional ability to selectively reduce the proportion of cancer stem cells within a number of cancer cell lines. Efficient single step strategies for the preparation of hydroxamic acid hybrids of this compound varying in N- and O-alkylation are presented.